T-wave inversion through inhom*ogeneous voltage diffusion within the FK3V cardiac model (2024)

Angelaki, E., Lazarides, N., Barmparis, G. D., Kourakis, I., Marketou, M. E., & Tsironis, G. P. (2024). T-wave inversion through inhom*ogeneous voltage diffusion within the FK3V cardiac model. Chaos, 34(4), Article 043140. https://doi.org/10.1063/5.0187655

Angelaki, E. ; Lazarides, N. ; Barmparis, G. D. et al. / T-wave inversion through inhom*ogeneous voltage diffusion within the FK3V cardiac model. In: Chaos. 2024 ; Vol. 34, No. 4.

@article{5b5fccc45d294217bc5b01d08f2647c0,

title = "T-wave inversion through inhom*ogeneous voltage diffusion within the FK3V cardiac model",

abstract = "The heart beats are due to the synchronized contraction of cardiomyocytes triggered by a periodic sequence of electrical signals called action potentials, which originate in the sinoatrial node and spread through the heart{\textquoteright}s electrical system. A large body of work is devoted to modeling the propagation of the action potential and to reproducing reliably its shape and duration. Connection of computational modeling of cells to macroscopic phenomenological curves such as the electrocardiogram has been also intense, due to its clinical importance in analyzing cardiovascular diseases. In this work, we simulate the dynamics of action potential propagation using the three-variable Fenton-Karma model that can account for both normal and damaged cells through a the spatially inhom*ogeneous voltage diffusion coefficient. We monitor the action potential propagation in the cardiac tissue and calculate the pseudo-electrocardiogram that reproduces the R and T waves. The R-wave amplitude varies according to a double exponential law as a function of the (spatially hom*ogeneous, for an isotropic tissue) diffusion coefficient. The addition of spatial inhom*ogeneity in the diffusion coefficient by means of a defected region representing damaged cardiac cells may result in T-wave inversion in the calculated pseudo-electrocardiogram. The transition from positive to negative polarity of the T-wave is analyzed as a function of the length and the depth of the defected region.",

author = "E. Angelaki and N. Lazarides and Barmparis, {G. D.} and Ioannis Kourakis and Marketou, {Maria E.} and Tsironis, {G. P.}",

note = "Publisher Copyright: {\textcopyright} 2024 Author(s).",

year = "2024",

month = apr,

day = "1",

doi = "10.1063/5.0187655",

language = "British English",

volume = "34",

journal = "Chaos",

issn = "1054-1500",

publisher = "American Institute of Physics",

number = "4",

}

Angelaki, E, Lazarides, N, Barmparis, GD, Kourakis, I, Marketou, ME & Tsironis, GP 2024, 'T-wave inversion through inhom*ogeneous voltage diffusion within the FK3V cardiac model', Chaos, vol. 34, no. 4, 043140. https://doi.org/10.1063/5.0187655

T-wave inversion through inhom*ogeneous voltage diffusion within the FK3V cardiac model. / Angelaki, E.; Lazarides, N.; Barmparis, G. D. et al.
In: Chaos, Vol. 34, No. 4, 043140, 01.04.2024.

Research output: Contribution to journal › Article › peer-review

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T1 - T-wave inversion through inhom*ogeneous voltage diffusion within the FK3V cardiac model

AU - Angelaki, E.

AU - Lazarides, N.

AU - Barmparis, G. D.

AU - Kourakis, Ioannis

AU - Marketou, Maria E.

AU - Tsironis, G. P.

N1 - Publisher Copyright:© 2024 Author(s).

PY - 2024/4/1

Y1 - 2024/4/1

N2 - The heart beats are due to the synchronized contraction of cardiomyocytes triggered by a periodic sequence of electrical signals called action potentials, which originate in the sinoatrial node and spread through the heart’s electrical system. A large body of work is devoted to modeling the propagation of the action potential and to reproducing reliably its shape and duration. Connection of computational modeling of cells to macroscopic phenomenological curves such as the electrocardiogram has been also intense, due to its clinical importance in analyzing cardiovascular diseases. In this work, we simulate the dynamics of action potential propagation using the three-variable Fenton-Karma model that can account for both normal and damaged cells through a the spatially inhom*ogeneous voltage diffusion coefficient. We monitor the action potential propagation in the cardiac tissue and calculate the pseudo-electrocardiogram that reproduces the R and T waves. The R-wave amplitude varies according to a double exponential law as a function of the (spatially hom*ogeneous, for an isotropic tissue) diffusion coefficient. The addition of spatial inhom*ogeneity in the diffusion coefficient by means of a defected region representing damaged cardiac cells may result in T-wave inversion in the calculated pseudo-electrocardiogram. The transition from positive to negative polarity of the T-wave is analyzed as a function of the length and the depth of the defected region.

AB - The heart beats are due to the synchronized contraction of cardiomyocytes triggered by a periodic sequence of electrical signals called action potentials, which originate in the sinoatrial node and spread through the heart’s electrical system. A large body of work is devoted to modeling the propagation of the action potential and to reproducing reliably its shape and duration. Connection of computational modeling of cells to macroscopic phenomenological curves such as the electrocardiogram has been also intense, due to its clinical importance in analyzing cardiovascular diseases. In this work, we simulate the dynamics of action potential propagation using the three-variable Fenton-Karma model that can account for both normal and damaged cells through a the spatially inhom*ogeneous voltage diffusion coefficient. We monitor the action potential propagation in the cardiac tissue and calculate the pseudo-electrocardiogram that reproduces the R and T waves. The R-wave amplitude varies according to a double exponential law as a function of the (spatially hom*ogeneous, for an isotropic tissue) diffusion coefficient. The addition of spatial inhom*ogeneity in the diffusion coefficient by means of a defected region representing damaged cardiac cells may result in T-wave inversion in the calculated pseudo-electrocardiogram. The transition from positive to negative polarity of the T-wave is analyzed as a function of the length and the depth of the defected region.

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Angelaki E, Lazarides N, Barmparis GD, Kourakis I, Marketou ME, Tsironis GP. T-wave inversion through inhom*ogeneous voltage diffusion within the FK3V cardiac model. Chaos. 2024 Apr 1;34(4):043140. doi: 10.1063/5.0187655